My solution is mixed into the bottle that the DMSO came in which has a roll on applicator. When I started I was applying it nightly or every other night. However do to the following side effects I began applying in the morning. Cortisol levels are generally highest in the morning.
PS(Phosphatidylserine) interacts with the central nervous system to slow down production of cortisol which is what we want. However, cortisol is important and too little cortisol will produce a variety of symptoms related to the CNS. Most notably and annoyingly to me was a hyperkinetic gallbladder. Cortisol and bile production are inversely related. The more cortisol in your body the less bile you produce otherwise the less cortisol the more bile is produced. Some people experienced heartburn but not me. But whenever I had eaten the bile was released from my galbladder and would go through my intestinal tract very quickly. I was usually making my way to the bathroom within an hour after eating.
Other symptoms include hypersomnia and headaches. Since switching application time from the evening to the morning this has mostly gone away.